5-MTHF (5-Methyltetrahydrofolate) is the active form of folic acid (vitamin B9) that the body can use directly without requiring conversion by the MTHFR enzyme. It is essential because it supports the production of neurotransmitters (such as serotonin, dopamine, and norepinephrine) through the methylation process, which influences mood, memory, and overall cognitive function.
5-MTHF acts as a methyl donor in the production of S-adenosylmethionine (SAMe), which is required for the synthesis of neurotransmitters that regulate mood. Folate deficiency or impaired folate metabolism (for example, due to MTHFR gene mutations) can reduce neurotransmitter levels, and increase the risk of depression and anxiety. Supplementation with 5-MTHF helps normalize this pathway and may improve symptoms of mood disorders, depression, and anxiety.
5-MTHF does not directly replace antidepressants or anxiolytics, but it is often used as an adjunct to enhance their effectiveness. Studies have shown that adding 5-MTHF can improve the response to selective serotonin reuptake inhibitors (SSRIs), particularly in patients who do not respond well to antidepressant monotherapy.
Yes. 5-MTHF supports brain health by improving methylation cycles and lowering homocysteine levels—a neurotoxic amino acid associated with cognitive decline and increased dementia risk when elevated. Supplementation with 5-MTHF may help improve memory and focus, especially in older adults or individuals with impaired folate metabolism.
Yes, HY-FOLIC can be safely taken by most individuals, particularly those with MTHFR mutations, which impair the conversion of folic acid into its active form. However, as with any supplement, it is important to consult a healthcare professional first—especially if you are on antidepressants, antiepileptic medications, or have chronic medical conditions. It is also recommended for pregnant and breastfeeding women, as folate demand increases significantly during these periods to support fetal and infant development.
Yes, especially for individuals with folate metabolism issues such as MTHFR polymorphisms. 5-MTHF is already active and does not require conversion. It also crosses the blood-brain barrier more efficiently and does not cause an accumulation of unmetabolized folic acid (UMFA), which has been linked to potential immune and neurological concerns.
Based on Gynecologist perspective, 5-MTHF is more reliable in preventing neural tube defects and supporting healthy pregnancy outcomes in women with impaired folate metabolism. And then, based on Cardiologist perspective, 5-MTHF helps lower homocysteine levels, which are associated with cardiovascular risk (stroke, atherosclerosis, thrombosis).
Yes. Studies have shown that 5-MTHF is generally safe for long-term use when taken at recommended doses under medical supervision. Unlike folic acid, it does not lead to the accumulation of unmetabolized folic acid in the bloodstream and is more efficiently metabolized by the body.
Folate is required for DNA synthesis, fetal brain and nervous system development, and red blood cell formation. Folate deficiency increases the risk of Neural Tube Defects (NTDs) such as spina bifida and anencephaly.
Yes. 5-MTHF has been studied to be safe and effective in pregnancy. The European Food Safety Authority (EFSA) has approved 5-MTHF as a folate source.
